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Considering SOD and miRNA analysis as potential prognostic markers in white lesion malignant transformation: A report
Zuzana Drotárová1, Miroslava Rabajdová2, Mária Mareková2
1Department of Stomatology and Maxilofacial Surgery, L. Pasteur University Hospital, Košice, Slovak Republic.
Rationale:
Predictive biomarkers can be effective in the identification of the oral leukoplakia with an increased probability of malignant transformation.
Patients Concerns:
A 63-year-old patient presents with persistent burning sensations throughout the oral cavity, accompanied by a white lesion on the tongue. Additionally, a 57-year-old patient with multiple white lesions in the oral cavity.
Diagnosis:
Histopathological analysis of the excised tissue.
Interventions:
Changes in the expression miRNAs (miR17, miR206, and miR23), the activity of antioxidant enzymes (superoxide dismutase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase), and concentration of reduced glutathione were detected, followed by meta-analysis of previous studies.
Outcomes:
In both patients (verrucous leukoplakia, oral squamous cell carcinoma) upregulated expression of miR-23a, miR-17, and downregulated expression of miR206 were detected when compared to healthy individuals. In the plasma of a patient diagnosed with carcinoma, higher activity of antioxidant enzymes connected to glutathione was measured in comparison to healthy individuals.
Lessons:
The connection between miRNA expression changes, the increase in glutathione-S-transferase and especially the decrease in superoxide dismutase activities in patients with white lesion potential malignant transformation using the provided statistical analysis was confirmed.
