Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

40
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
40
Reducing Line Loss01:18

Reducing Line Loss

144
In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss...
144
Problem Solving: Dimensional Analysis01:08

Problem Solving: Dimensional Analysis

3.3K
Every mathematical equation that connects separate distinct physical quantities must be dimensionally consistent, which implies it must abide by two rules. For this reason, the concept of dimension is crucial. The first rule is that an equation's expressions on either side of an equality must have the exact same dimension, i.e., quantities of the same dimension can be added or removed. The second rule stipulates that all popular mathematical functions, such as exponential, logarithmic, and...
3.3K
Linear Approximation in Frequency Domain01:26

Linear Approximation in Frequency Domain

85
Linear systems are characterized by two main properties: superposition and homogeneity. Superposition allows the response to multiple inputs to be the sum of the responses to each individual input. Homogeneity ensures that scaling an input by a scalar results in the response being scaled by the same scalar.
In contrast, nonlinear systems do not inherently possess these properties. However, for small deviations around an operating point, a nonlinear system can often be approximated as linear....
85
Linear Approximation in Time Domain01:21

Linear Approximation in Time Domain

62
Nonlinear systems often require sophisticated approaches for accurate modeling and analysis, with state-space representation being particularly effective. This method is especially useful for systems where variables and parameters vary with time or operating conditions, such as in a simple pendulum or a translational mechanical system with nonlinear springs.
For a simple pendulum with a mass evenly distributed along its length and the center of mass located at half the pendulum's length,...
62
Unsymmetric Loading of Thin-Walled Members: Problem Solving01:07

Unsymmetric Loading of Thin-Walled Members: Problem Solving

90
The shear center of a channel section with uniform thickness, height, and width, is determined by computing the shear force in the member and calculating the moments of inertia of the sections.
To compute the shear forces, find the shear flow at a specific distance from the endpoint using the vertical shear and the moment of inertia values. The total shear force on the flange is calculated by integrating the shear flow from one end of the flange to the other.
Next, calculate the moments of...
90

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Limited validity of an AI-powered app for dietary assessment in females with obesity.

NPJ digital medicine·2026
Same author

Meta-analysis models with group structure for pleiotropy detection at gene and variant level using summary statistics from multiple datasets.

Biostatistics (Oxford, England)·2025
Same author

Two-stage sampling for better survival model performance.

BMC medical research methodology·2025
Same author

Adjusted predictions for generalized estimating equations.

Biometrics·2025
Same author

A Kidney Transplant Support System for Patient-Clinician Shared Decision-Making.

Journal of medical systems·2025
Same author

Ex vivo prediction of the sensitization potential of biocides.

Regulatory toxicology and pharmacology : RTP·2025
Same journal

When to Adjust for Multiple Testing: A Unifying Guiding Principle.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Ensuring Quality in Preclinical Research: The Importance of Being Human.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Addressing Cluster-Level Treatment Effect Heterogeneity in Sample Size Determination for Hierarchical 2 × 2 Factorial Designs.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

A Multiple Imputation Approach to Distinguish Curative From Life-Prolonging Effects in the Presence of Missing Covariates.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Tests for Categorical Data Beyond Pearson: A Distance Covariance and Energy Distance Approach.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Nonparametric Estimation of the Patient-Weighted While-Alive Estimand.

Biometrical journal. Biometrische Zeitschrift·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.0K

Best Subset Solution Path for Linear Dimension Reduction Models Using Continuous Optimization.

Benoit Liquet1,2, Sarat Moka1,3, Samuel Muller1,4

  • 1School of Mathematical and Physical Sciences, Macquarie University, Sydney, Australia.

Biometrical Journal. Biometrische Zeitschrift
|December 17, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a novel best subset solution path method for principal component analysis and partial least squares. The approach enhances interpretability in high-dimensional data analysis, improving variable selection.

Keywords:
best subset solution pathcontinuous optimizationpartial least squareprincipal componentsparsity

More Related Videos

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
13:54

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM

Published on: August 18, 2023

4.4K
Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

949

Related Experiment Videos

Last Updated: Jun 4, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.0K
A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
13:54

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM

Published on: August 18, 2023

4.4K
Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

949

Area of Science:

  • Multivariate Statistics
  • Machine Learning
  • Data Science

Background:

  • Variable selection is challenging in high-dimensional data, where the number of variables exceeds observations.
  • Principal Component Analysis (PCA) and Partial Least Squares (PLS) are popular linear dimension-reduction techniques.
  • Interpreting principal components can be difficult with a large number of original variables.

Purpose of the Study:

  • To integrate the best subset solution path method into PCA and PLS frameworks.
  • To address the interpretability challenge of principal components in high-dimensional data.
  • To offer a new approach for identifying the most relevant variables for dimension reduction.

Main Methods:

  • Casting the best subset solution path method into PCA and PLS frameworks.
  • Utilizing a continuous optimization algorithm for the best subset solution path.
  • Empirical studies and analysis of two real-world datasets.

Main Results:

  • The proposed approach demonstrates efficacy in providing a best subset solution path.
  • Successful application of the algorithm to PCA and PLS frameworks.
  • Validation through the analysis of two distinct real datasets.

Conclusions:

  • The novel method enhances the interpretability of principal components by selecting the most relevant variables.
  • The continuous optimization algorithm provides an effective solution for best subset selection in PCA and PLS.
  • The approach offers a valuable tool for high-dimensional data analysis across various scientific fields.