Accuracy analysis of cholesterol analyzer in detecting dyslipidemia in truck drivers

Area of Science:

• Clinical Chemistry
• Cardiovascular Disease Diagnostics
• Point-of-Care Testing

Background:

• Cardiovascular diseases (CVD) represent a significant global health burden.
• Timely diagnosis of CVD risk factors, such as dyslipidemia, is critical, particularly in high-risk occupational groups like truck drivers.
• Rapid diagnostic tools are essential for effective and prompt patient management.

Purpose of the Study:

• To evaluate the diagnostic accuracy of the Mission® analyzer for lipid profile measurements (HDL-C, TG, TC) compared to standard laboratory methods.
• To assess the utility of the Mission® analyzer for initial screening and cardiovascular risk assessment in truck drivers.
• To determine the correlation and agreement between point-of-care and laboratory lipid measurements.

Main Methods:

• A blinded cross-sectional study involving 108 truck drivers (aged 30-64) in Brazil.
• Comparison of lipid profile results (HDL, TG, TC) obtained from the Mission® analyzer against established laboratory testing.
• Statistical analyses included Spearman correlation, linear regression, and Bland-Altman analysis to assess accuracy and agreement.

Main Results:

• The Mission® analyzer demonstrated good accuracy with Area Under the Curve (AUC) values of 0.77 for HDL, 0.97 for TG, and 0.87 for TC.
• High sensitivity and specificity were observed for TG (0.96 and 0.98, respectively).
• Bland-Altman analysis indicated biases of -4.5 for HDL, 12.4 for TC, and -42.8 for TG when compared to laboratory results.

Conclusions:

• The Mission® analyzer provides accurate rapid screening for dyslipidemia and aids in Framingham Global Risk Score calculation among truck drivers.
• The device is a valuable tool for initial risk assessment in occupational health settings.
• Confirmation with laboratory testing is advised for definitive diagnosis and guiding treatment strategies.