TEleRehabilitation foR Aphasia (TERRA) phase II trial design

Area of Science:

• Neurorehabilitation
• Speech-Language Pathology
• Stroke Recovery

Background:

• Aphasia therapy is crucial for chronic stroke survivors, but access is limited by provider availability and transportation.
• Telerehabilitation presents a viable strategy to overcome these access barriers and enhance therapy delivery.

Purpose of the Study:

• To design and detail the methodology of the TEleRehabilitation foR Aphasia (TERRA) trial.
• To assess the non-inferiority of telerehabilitation compared to in-clinic aphasia therapy for chronic post-stroke aphasia.

Main Methods:

• A prospective, randomized, rater-blinded, multicenter phase II non-inferiority trial.
• 100 adults with chronic post-stroke aphasia randomized to receive 30 days of remote or in-clinic therapy (45 min/day).
• Therapy included 15 days of semantic and 15 days of phonologic approaches.

Main Results:

• This section is not available in the provided abstract.

Conclusions:

• The TERRA trial design facilitates testing the efficacy of telerehabilitation for aphasia.
• Findings will inform a potential definitive phase III trial to establish telerehabilitation as a standard of care.