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Creutzfeldt-Jakob disease: A case report
Fahad Rasool Butt1, Thanansayan Dhivagaran1, Syed Naqvi1,2
1Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Radiology Case Reports
|December 17, 2024
Summary
Creutzfeldt-Jakob Disease (CJD) is a rare, fatal prion disease. This case report details a 62-year-old female with rapidly progressive dementia, highlighting diagnostic findings and autopsy confirmation.
Area of Science:
- Neurology
- Pathology
- Prion Diseases
Background:
- Creutzfeldt-Jakob Disease (CJD) is a rare, fatal neurodegenerative disorder.
- It is caused by infectious prion proteins.
- CJD presents with rapidly progressive dementia, ataxia, myoclonus, memory loss, visual disturbances, and personality changes.
Observation:
- This case report focuses on a 62-year-old female with a progressive cognitive decline.
- Her symptoms led to death within six months of presentation.
- Diagnostic evaluations included cerebrospinal fluid analysis, MRI, and electroencephalography.
Findings:
- Autopsy revealed spongiform changes, neuronal loss, and astrogliosis.
- These pathological findings are consistent with a diagnosis of Creutzfeldt-Jakob Disease.
- The rapid disease course and specific neuropathological hallmarks were noted.
Implications:
- This case underscores the importance of considering CJD in rapidly progressive dementia.
- Diagnostic tools like MRI and EEG can aid in early identification.
- Autopsy remains crucial for definitive diagnosis and understanding disease pathology.
