Solvent-Dependent Divergent Cyclization of Bicyclo[1.1.0]butanes
Fuhao Zhang1, Subhabrata Dutta1, Alessia Petti1
1Organisch-Chemisches Institut, Universität Münster, Corrensstraße 36, 48149, Münster, Germany.
Abstract:
Bicyclo[1.1.0]butanes (BCBs) have recently garnered significant research interest as versatile precursors for synthesizing potential [n.1.1] bioisosteres and multi-functionalized cyclobutanes in a straightforward and atom-economical manner. Here, we report a solvent-dependent divergent cyclization of BCBs that provides highly diastereospecific decorated cyclobutanes and oxygen-containing bicyclo[3.1.1]heptanes (BCHeps), which serve as bioisosteres of meta-substituted arenes. Additionally, an unprecedented 1,2-difunctionalization reaction mode for BCBs was explored, thus expanding the chemical space of arene bioisosteres and highly functionalized cyclobutanes.
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