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Light-Chain Myeloma Presented as Osseus Tumors: A Case Report
Shengmin Huang1, Mustafa Wasifuddin1, Amulya Bellamkonda1
1Brookdale University Hospital Medical Center, Brooklyn, NY, USA.
Light-chain multiple myeloma (LCMM) can present as rare osseous tumors. Early diagnosis and treatment, like daratumumab-based regimens, are crucial for managing this uncommon plasma cell neoplasm.
Area of Science:
- Oncology
- Hematology
Background:
- Light-chain multiple myeloma (LCMM) is a rare plasma cell neoplasm.
- It is typically associated with kidney disease and lytic bone lesions.
Observation:
- A 63-year-old male presented with rib pain, initially attributed to an isolated bone tumor.
- Imaging revealed multiple lytic bone lesions, and biopsy confirmed kappa light chain-producing plasma cells.
Findings:
- The patient's osseous tumors were diagnosed as LCMM.
- Treatment with daratumumab, bortezomib, lenalidomide, and dexamethasone led to significant clinical improvement.
Implications:
- This case highlights the diagnostic challenges of LCMM presenting as bone tumors.
- It emphasizes the importance of including LCMM in the differential diagnosis for unexplained bone lesions.
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