Non-Ti MXenes: new biocompatible and biodegradable candidates for biomedical applications

MXenes are a class of two-dimensional nanomaterials with the general formula M_n+1X_nT_x, where M denotes a transition metal, X denotes either carbon or nitrogen and T_x refers to surface terminations, such as -OH, -O, -F or -Cl. The unique properties of MXenes, including their tunable surface chemistry and high surface area-to-volume ratio, make them promising candidates for various biomedical applications, such as targeted drug delivery, photothermal therapy and so on. Among the family of MXenes, titanium (Ti)-based MXenes, especially Ti₃C₂T_x, have been extensively explored for biomedical applications. However, despite their potential, Ti-based MXenes have shown some limitations, such as low biocompatibility. Recent studies have also indicated that Ti MXenes may disrupt spermatogenesis and accumulate in the uterus. Non-Ti MXenes are emerging as promising alternatives to Ti-based MXenes due to their superior biodegradability and enhanced biocompatibility. Recently, non-Ti MXenes have been explored for a range of biomedical applications, including drug delivery, photothermal therapy, chemodynamic therapy and sonodynamic therapy. In addition, some non-Ti MXenes exhibit enzyme-mimicking activity, such as superoxide dismutase and peroxidase-like functions, which play a major role in scavenging reactive oxygen species (ROS). This review discusses the properties of non-Ti MXenes, such as biocompatibility, biodegradability, antibacterial activity, and neuroprotective effects, highlighting their potential in various biomedical applications. These properties can be leveraged to mitigate oxidative stress and develop safe and innovative strategies for managing chronic diseases. This review provides a comprehensive analysis of the various biomedical applications of non-Ti MXenes, including their use in drug delivery and combinatorial therapies and as nanozymes for sensing and therapeutic purposes. The theranostic applications of non-Ti MXenes are also discussed. Finally, the antibacterial properties of non-Ti MXenes and the proposed mechanisms are discussed. The review concludes with a summary of the key findings and future perspectives. In short, this review provides a thorough analysis of the biomedical applications of non-Ti MXenes, emphasizing their unique properties, potential opportunities and challenges in the field.