Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parametric Survival Analysis: Weibull and Exponential Methods01:14

Parametric Survival Analysis: Weibull and Exponential Methods

356
Parametric survival analysis models survival data by assuming a specific probability distribution for the time until an event occurs. The Weibull and exponential distributions are two of the most commonly used methods in this context, due to their versatility and relatively straightforward application.
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
356
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

40
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
40
Molecular Weight of Step-Growth Polymers01:08

Molecular Weight of Step-Growth Polymers

2.1K
Step growth polymerization involves bi or multifunctional monomers. Bifunctional monomers react to form linear step growth polymers, whereas multifunctional monomers react to form non-linear or branched polymers.
As the step-growth polymerization involves step-wise condensation of monomers, the molecular weight also builds up eventually. Consequently, high molecular weight polymers are obtained at the late stages of the polymerization, where 99% of monomers have been consumed.
The extent of the...
2.1K
Wald-Wolfowitz Runs Test II01:17

Wald-Wolfowitz Runs Test II

179
The Wald-Wolfowitz runs test, commonly referred to as the runs test, is a nonparametric test used to assess the randomness of ordered data. The test evaluates the number of runs, which are consecutive sequences of similar elements within the data. If the number of runs is significantly higher or lower than expected, the data is considered non-random, indicating a detectable pattern or structure.
For binary data, runs are identified using symbols such as + and −, or equivalently, 1s and...
179
Genetic Drift03:33

Genetic Drift

39.4K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
39.4K
Wald-Wolfowitz Runs Test I01:17

Wald-Wolfowitz Runs Test I

604
The Wald-Wolfowitz test, also known as the runs test, is a nonparametric statistical test used to assess the randomness of a sequence of two different types of elements (e.g., positive/negative values, successes/failures). It examines whether the order of the elements in a sequence is random or if there is a pattern or trend present. This nonparametric test applies to any ordered data despite the population and sample data distribution, even if a higher sample size is available.
The test works...
604

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leveraging MedlinePlus to Improve Health Information Access Among Patients and Caregivers: Systematic Literature Review.

JMIR medical informatics·2026
Same author

User perceptions and preferences for GeoHealth tools: A qualitative focus group study of non-expert and expert users.

Digital health·2026
Same author

Cultural Adaptation of a Web-Based Ostomy Care Intervention for Hispanic Patients With Cancer and Caregivers: Mixed Methods Study.

JMIR cancer·2026
Same author

Design characteristics of sequential multiple assignment randomised trials (SMARTs) for human health: a scoping review of studies between 2009 and 2024.

BMJ open·2025
Same author

Effects Among the Affected.

Statistics in medicine·2025
Same author

Using precision medicine methods to identify disease stages for chronic limb-threatening ischemia in participants of the BEST-CLI trial.

Journal of vascular surgery·2025
Same journal

Analysis of strength degradation of coal and rock masses and stability of mined areas under long term immersion environment.

PloS one·2026
Same journal

Biogenic Silver-Selenium nanocomposite with anticancer activity and potent efficacy against vancomycin-resistant Staphylococcus aureus.

PloS one·2026
Same journal

Preparation and physicochemical characterization of a biodegradable chitosan/carboxymethyl cellulose hydrogel synthesized in NaOH/urea medium.

PloS one·2026
Same journal

Action-guilt, survivor-guilt, and depression in combat-related PTSD.

PloS one·2026
Same journal

Explainable machine learning for predicting activities of daily living at discharge in stroke patients: A retrospective study using SHAP interpretability.

PloS one·2026
Same journal

Deep learning based two-way feature depiction model for brain tumor detection.

PloS one·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2025

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.4K

Stochastic step-wise feature selection for Exponential Random Graph Models (ERGMs).

Helal El-Zaatari1, Fei Yu2, Michael R Kosorok1

  • 1Department of Biostatistics, University of North Carolina, Chapel Hill, NC, United States of America.

Plos One
|December 17, 2024
PubMed
Summary
This summary is machine-generated.

This study presents a new method for selecting variables in Exponential Random Graph Models (ERGM) to improve social network analysis. The approach tackles ERGM degeneracy and complexity, offering accurate, non-degenerate network models for diverse scientific applications.

More Related Videos

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

637
Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.1K

Related Experiment Videos

Last Updated: Jun 4, 2025

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.4K
Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

637
Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.1K

Area of Science:

  • Social Network Analysis
  • Statistical Modeling
  • Computational Social Science

Background:

  • Exponential Random Graph Models (ERGM) are powerful tools for analyzing social networks.
  • Traditional ERGM methods face challenges with degeneracy and computational complexity.
  • Accurate modeling of complex network structures, both directed and undirected, remains a significant challenge.

Purpose of the Study:

  • To introduce a novel methodology for endogenous variable selection in ERGMs.
  • To address and overcome the issues of ERGM degeneracy and computational complexity.
  • To provide a robust framework for analyzing and interpreting social networks across various scientific disciplines.

Main Methods:

  • A systematic step-wise feature selection process is integrated into the ERGM framework.
  • The methodology effectively manages intractable normalizing constants inherent in ERGMs.
  • The approach is designed for adaptability to both directed and undirected network data.

Main Results:

  • The novel methodology successfully generates accurate and non-degenerate network models.
  • Empirical application to nine real-life binary networks demonstrates effectiveness.
  • The method accommodates network dependencies and provides meaningful insights into complex interactions.

Conclusions:

  • The proposed methodology offers a robust solution for endogenous variable selection in ERGMs.
  • It enhances the ability to model and interpret complex social networks accurately.
  • This work lays the foundation for future advancements in statistical network analysis techniques.