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Evaluation of the treatment effectiveness in children with coronavirus infection
Olesya M Horlenko1, Khrystyna A Hechko1, Lyubomyra B Prylypko1
1UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.
Insights
Treatment for children with Coronavirus infection showed positive results, normalizing vitamin D3 and Zinc levels. Inflammatory markers significantly decreased post-treatment, indicating improved health outcomes.
Area of Science:
- Pediatric infectious diseases
- Immunology
- Biochemistry
Background:
- Coronavirus infection poses significant health risks to children, impacting various physiological markers.
- Understanding treatment effectiveness is crucial for managing pediatric COVID-19 cases.
Purpose of the Study:
- To evaluate the effectiveness of a treatment regimen in children diagnosed with Coronavirus infection.
- To analyze changes in clinical and biochemical parameters following treatment.
Main Methods:
- A study involving 68 children with confirmed Coronavirus infection, compared to a control group of 28.
- Analysis of complete blood count (CBC), vitamin D3, Zinc, immunoglobulin levels, and inflammatory markers before and after treatment.
Main Results:
- Treatment led to positive dynamics in most CBC parameters, except Platelets and Eosinophils.
- Vitamin D3 and Zinc levels normalized, while immunoglobulin levels showed an initial increase followed by normalization.
- Significant reductions were observed in inflammatory markers such as IL-1, IL-6, TNF-α, CRP, and D-dimer post-treatment.
Conclusions:
- The studied treatment is effective in improving clinical and biochemical parameters in children with Coronavirus infection.
- Treatment helps normalize key indicators and reduce inflammation, contributing to recovery.
- Further monitoring indicated sustained positive trends and normalization of certain metabolic markers over six months.
Objective:
Aim: To study and analyze the treatment effectiveness in children with identified Coronavirus infection..
Patients And Methods:
Materials and Methods: included the treatment and analysis of the study results of of children (n=68, aged 14.36}3.62 years), with confirmed Coronavirus infection, who were observed in outpatient settings and in comparison with the control group (n=28).
Results:
Results: Positive dynamics after treatment were observed in all parameters of the CBC (р4<0.01-0.03), except in the level of Platelets (р1=0.65; р2=0.3, р3=0.21, р4=0.59) and Eosinophils (p1=0.40, p4=0.06). The levels of vitamin D3 and Zn were below the reference limit at the initial stage of the study and reached the physiological norms (р2=0.14,р2=0.09, respectively). Increasings of Ig M levels in 2.7 times, Ig E - in 10.6 and Ig A -in 3.3 were observed on the starting stage and have positive trend with the normalization of the levels after 6 months, which was confirmed by statistical significance (р4=0 ,06, p4=0.10, p4=0.54, respectively).
Conclusion:
Conclusions: A level decrease in the the obtained indicators was observed after treatment in the next: IL-1 in 39.3 times, IL-4 in 6.6 times, IL-6 in 14.3 times, TNF-αin 49.2 times, γ-IFN in 11.2 times, D-dimer -in 14.1 times, Neopterin -in 10.1 times, CRP- in 5.4 times and Fibrinogen -1.9 times. The level of Anti IgGSARS-CoV-2S1-RBD exceeded the permissible level in 13.8 times. The levels of Adiponectin, Leptin and C-peptide significantly have decreased after treatment (p1<0.01) and after 6 months.
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