The severity and outcome of Covid-19 depend on the various activities of the renin-angiotensin-aldosterone system, level of the opioid growth factor, [met5]-enkephalin and pre-existing comorbidities
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View abstract on PubMed
Summary
This summary is machine-generated.Severe COVID-19 outcomes are linked to renin-aldosterone system activity and methionine-enkephalin levels. These biomarkers predict mortality in patients with comorbidities and preterm birth in pregnant individuals with COVID-19.
Area Of Science
- Endocrinology
- Infectious Diseases
- Oncology
Background
- COVID-19 severity is influenced by complex physiological factors.
- The renin-aldosterone system (RAS) and enkephalinergic systems play critical roles in various diseases.
- Understanding their interplay in COVID-19 is crucial for predicting outcomes.
Purpose Of The Study
- To evaluate methionine-enkephalin and RAS activity in severe COVID-19 patients.
- To compare these markers in COVID-19 patients with comorbidities (renal cell cancer, critical limb ischemia) and adverse pregnancy outcomes.
- To identify predictive biomarkers for mortality and preterm birth.
Main Methods
- Case-control study including healthy donors, COVID-19 patients, and COVID-19 patients with comorbidities or pregnancy.
- Measurement of methionine-enkephalin, plasma renin activity, and plasma aldosterone via radioimmunoassay.
- Statistical and graphical analyses using Statistica 7.0 and MedCalc software.
Main Results
- Hyperreninemia with hypoaldosteronism and inhibited enkephalinergic activity is fatal in COVID-19.
- Methionine-enkephalin, aldosterone, and renin activity predict mortality in COVID-19 with renal cell carcinoma.
- Renin activity is the strongest mortality predictor in COVID-19 with critical limb ischemia.
- Methionine-enkephalin predicts preterm birth; plasma renin activity predicts adverse outcomes in pregnant COVID-19 patients.
Conclusions
- COVID-19 patient outcomes are significantly influenced by the activity of the renin-angiotensin-aldosterone and enkephalinergic systems.
- Specific biomarkers within these systems have predictive value for mortality and pregnancy complications.
- Tailoring treatment based on these endocrine markers may improve patient management.
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