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The correlation of bisphenol A exposure on inflammatory cytokines in preschool children

Wenya Cai1, Qingshan Yan2, Yuhong Deng3

  • 1Department of Public Health, Guangzhou Medical University, Guangzhou 511436, China; Department of Health Care, Guangdong Women and Children Hospital, Guangzhou 511442, China.

Cytokine
|December 17, 2024
PubMed

Insights

Bisphenol A (BPA) exposure in preschool children is linked to lower IL-10 levels, especially in girls. Overweight/obese children exposed to BPA showed increased IL-6 levels, suggesting a connection between BPA and inflammation.

Area of Science:

  • Environmental Health
  • Pediatric Endocrinology
  • Immunology

Background:

  • Bisphenol A (BPA) is an endocrine-disrupting chemical with potential links to obesity via inflammatory pathways.
  • Understanding BPA's impact on inflammatory markers in children is crucial for public health.
  • Preschool-aged children may be particularly vulnerable to environmental exposures like BPA.

Purpose of the Study:

  • To investigate the correlation between Bisphenol A (BPA) exposure and cellular inflammatory factors in preschool children.
  • To explore potential sex-specific differences in the association between BPA and inflammation.
  • To examine the relationship between BPA exposure and inflammatory markers in relation to Body Mass Index (BMI) categories.

Main Methods:

  • A cohort of 155 preschool children (aged 4-6 years) provided urine and blood samples.
  • Urinary BPA levels were quantified using liquid chromatography-tandem mass spectrometry.
  • Six inflammatory cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ) were measured using flow fluorescence, with analyses stratified by gender and BMI.

Main Results:

  • Bisphenol A (BPA) was detected in 100% of urine samples, with a median concentration of 0.48 μg/L.
  • BPA exposure showed a negative correlation with IL-10 levels (r = -0.172, P < 0.05), particularly in girls (r = -0.257, P < 0.05).
  • In overweight/obese children, BPA exposure was positively correlated with IL-6 levels (r = 0.354, P < 0.05).

Conclusions:

  • Bisphenol A (BPA) exposure in preschool children is associated with reduced IL-10 levels, with a more pronounced effect observed in girls.
  • Increased IL-6 levels were correlated with BPA exposure in overweight/obese preschool children.
  • Further research is needed to elucidate the precise mechanisms linking Bisphenol A (BPA) and inflammatory factors.
Abstract

Keywords:
Bisphenol AChildren growthInflammatory cytokinesObesityPreschool children

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