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Silk-polyurethane composite based flexible electrochemical biosensing platform for pathogen detection.

Karri Trinadha Rao1, Rahul Gangwar1, Aditya Bhagavathi1

  • 1Department of Electrical Engineering, Indian Institute of Technology, Hyderabad, India, 502284.

Biosensors & Bioelectronics
|December 17, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed a flexible Silk-polyurethane (Silk-PU) composite film for wearable electronics. This robust, biocompatible substrate enables sensitive electrochemical detection of pathogens like E. coli, paving the way for advanced biosensors.

Keywords:
Bacterial detectionElectrochemical sensorEscherichia coliFlexible screen printed electrodeSilk-PU compositeToll-like receptor

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Electrochemistry

Background:

  • Flexible and wearable electronics require novel, low-cost, biocompatible substrates.
  • Natural biopolymers like Silk offer biocompatibility but lack long-term flexibility.
  • Developing robust, flexible substrates is crucial for fabricating advanced electronic devices and sensors.

Purpose of the Study:

  • To prepare and characterize a flexible Silk-polyurethane (Silk-PU) composite film for enhanced substrate properties.
  • To develop a scalable electrochemical biosensing platform using screen-printing techniques.
  • To demonstrate the platform's capability for sensitive pathogen detection and its potential for lab-on-chip integration.

Main Methods:

  • Fabrication and characterization of Silk-polyurethane composite films.
  • Development of a three-electrode electrochemical sensing system via screen-printing.
  • Modification of screen-printed electrodes (SPEs) with gold nanoparticles for pathogen detection.
  • Testing the substrate's flexibility and the biosensor's performance with E. coli detection.

Main Results:

  • The Silk-PU composite film exhibited excellent long-duration flexibility and robustness, even after rigorous bending tests.
  • An electrochemical biosensing platform was successfully developed on the Silk-PU substrate.
  • The platform demonstrated highly sensitive detection of E. coli, with a detection limit as low as 0.12 CFU/mL.
  • The substrate's properties remained unaffected throughout the functionalization and detection processes.

Conclusions:

  • The Silk-PU composite film is a promising flexible, biocompatible substrate for wearable electronics and biosensing applications.
  • The developed screen-printed electrochemical biosensor offers a scalable and sensitive platform for pathogen detection.
  • The platform's compatibility with microfluidics suggests potential for integrated lab-on-chip devices and multi-pathogen detection.