Do tissue-dwelling trypanosomes sustain transmission populations?
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Updated: Jun 4, 2025

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Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates
Published on: January 27, 2019
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Stephen D Larcombe1, Jane C Munday2, Richard McCulloch2
1University of Edinburgh, Institute for Immunology and Infection Research, School of Biological Sciences, Edinburgh, UK.
Trends in Parasitology
|December 17, 2024
Abstract:
Trypanosoma brucei infectious populations are marked by considerable diversity in the parasite's major antigen, the variant surface glycoprotein (VSG). However, most parasites in the bloodstream are non-replicating, questioning how VSG diversity arises. Beaver et al. show that extravascular parasites in host tissues many explain this paradox and provide insight into trypanosome transmission.

