Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
Metastasis02:30

Metastasis

5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Nuclear Localization Signals and Import01:46

Nuclear Localization Signals and Import

5.5K
Proteins targeted to the nucleus carry short stretches of amino acid sequences called the nuclear localization signal or NLS. Classical nuclear localization signals are of two types: monopartite and bipartite NLS. Monopartite classical NLS (cNLS) consists of a single cluster of 4-8 amino acids. Bipartite cNLS consists of two clusters of  2-3 amino acids and a 9-12 residue long proline-rich linker bridging the two clusters. Signal clusters are rich in positively charged amino acids such as...
5.5K
What is Cancer?02:12

What is Cancer?

10.5K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
10.5K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

7.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

8.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two-stage bone grafting for nasal correction in late-presenting patients with unilateral cleft: A 3-year comparative study.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2026
Same author

Co-occurring polycyclic aromatic hydrocarbons and heavy metals drive bacterial community shifts regulated by soil water content in China's Beiluo River riparian soils.

Ecotoxicology (London, England)·2026
Same author

PuMYB40 and PuWRKY75 synergistically enhance phosphate uptake and organic phosphorus hydrolysis under phosphate deficiency in poplar.

Plant physiology·2026
Same author

Crosstalk of metabolic cell death pathways in colorectal cancer: implications for precision therapy.

Apoptosis : an international journal on programmed cell death·2026
Same author

Dynamic Disulfide Bonds Enhanced Elastomer Scintillator for Self-Healing and High-Resolution CT Imaging.

Nano letters·2026
Same author

Correction: The multifaceted functions of selective autophagy in cancer: molecular basis, consequences, and clinical prospects.

Molecular cancer·2026

Related Experiment Video

Updated: Jun 4, 2025

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells
05:27

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells

Published on: June 16, 2023

1.4K

SE-lncRNAs in Cancer: Classification, Subcellular Localisation, Function and Corresponding TFs.

Yuxin Bao1, Songling Teng2, Hanjie Zhai1

  • 1Fourth Department of Orthopaedic Surgery, Central Hospital Affiliated To Shenyang Medical College, Shenyang, Liaoning, P. R. China.

Journal of Cellular and Molecular Medicine
|December 17, 2024
PubMed
Summary

Super-enhancer lncRNAs (SE-lncRNAs) are crucial in cancer, regulating progression via interactions with targets. Transcription factors (TFs) control SE-lncRNA expression, and their dysregulation drives cancer development.

Keywords:
ECM remodellingSE‐lncRNAscancersubcellular locationtranscriptional regulation

More Related Videos

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
06:09

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

11.9K
Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.4K

Related Experiment Videos

Last Updated: Jun 4, 2025

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells
05:27

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells

Published on: June 16, 2023

1.4K
Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
06:09

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

11.9K
Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.4K

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Long noncoding RNAs (lncRNAs) associated with super-enhancers (SEs), termed SE-lncRNAs, are increasingly recognized for their roles in cancer.
  • These SE-lncRNAs are implicated in cancer progression through diverse interactions with downstream molecular targets.
  • Their expression is modulated by transcription factors (TFs), whose dysregulation is linked to oncogenesis.

Purpose of the Study:

  • To review the characteristics, classification, and subcellular localization of SE-lncRNAs.
  • To summarize the roles of key TFs in regulating SE-lncRNA transcription and expression.
  • To examine the specific functions and underlying mechanisms of SE-lncRNAs in cancer progression.

Main Methods:

  • Literature review and synthesis of existing research on SE-lncRNAs and TFs.
  • Analysis of studies detailing SE-lncRNA characteristics, TF regulation, and cancer-related functions.
  • Compilation of evidence on the molecular mechanisms through which SE-lncRNAs influence cancer.

Main Results:

  • SE-lncRNAs exhibit diverse characteristics, classifications, and subcellular distributions.
  • Specific TFs play critical roles in the transcription and regulation of SE-lncRNAs.
  • SE-lncRNAs demonstrate distinct functions and mechanisms contributing to cancer progression.

Conclusions:

  • SE-lncRNAs are significant regulators in cancer, influenced by TF activity.
  • Understanding SE-lncRNA biology and TF interactions offers potential therapeutic avenues.
  • Further research into SE-lncRNA mechanisms can elucidate novel cancer targets.