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Depressive Symptoms and HIV Viral Suppression: A Systematic Review and Meta-analysis

  • 0School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA. bhuang2@albany.edu.
AIDS and Behavior +

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December 17, 2024

|

December 17, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Individuals without depression are more likely to achieve HIV viral suppression. Addressing depression in people living with HIV is crucial for improving treatment adherence and health outcomes.

Area Of Science

  • Public Health
  • Epidemiology
  • Mental Health

Background

  • Depression is a known factor affecting health outcomes in people living with HIV (PLWH).
  • Understanding the specific impact of depression on HIV viral suppression is critical for effective management.

Purpose Of The Study

  • To quantify the association between depression and HIV viral suppression through a meta-analysis.
  • To identify specific populations where this association is most pronounced.

Main Methods

  • Systematic literature search across major databases (PubMed, Web of Science, EBSCO, OVID) for studies from 2012-2022.
  • Meta-analysis of 16 studies including 80,103 participants, adhering to PRISMA guidelines.
  • Random effects model used for analysis, with data abstraction via Rayyan software.

Main Results

  • Individuals without depression were significantly more likely to achieve viral suppression (OR 1.30; 95% CI 1.15, 1.48).
  • This association was significant in the general PLWH population and cisgender women, but not statistically significant in cisgender men.
  • Subgroup analysis showed a positive association between absence of depression and viral suppression in cisgender women (OR 1.28; 95% CI 1.09, 1.50).

Conclusions

  • Absence of depression is positively associated with achieving HIV viral suppression, particularly in cisgender women.
  • Public health interventions for PLWH must integrate strategies for identifying and managing depressive symptoms.
  • Addressing depression can improve treatment adherence, reduce co-morbidities, and mitigate factors hindering viral suppression.

Keywords:

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