Advancements in Ocular Modelling and Simulations: Key Considerations and Case Studies.

Area of Science:

• Ophthalmology
• Pharmaceutics
• Biomedical Engineering

Background:

• The eye's complex structure necessitates specialized drug delivery systems.
• Ocular diseases require precise therapeutic interventions.
• Current ocular drug delivery methods face significant challenges.

Purpose of the Study:

• To review ocular biopharmaceutics, focusing on modeling and simulation.
• To explore drug delivery formulations and administration routes for ocular therapies.
• To highlight the role of ocular compartmental modeling in understanding eye diseases.

Main Methods:

• Comprehensive literature review of ocular biopharmaceutics.
• Analysis of ocular compartmental modeling and simulation techniques.
• Discussion of various ocular drug delivery formulations and administration routes.

Main Results:

• Ocular compartmental modeling provides critical insights into drug distribution and release kinetics.
• Understanding eye physiology is key to optimizing drug delivery.
• Various formulations offer distinct advantages and limitations for ocular drug delivery.

Conclusions:

• Ocular compartmental modeling and simulation are essential tools for advancing ocular drug delivery.
• Targeted drug delivery strategies can be significantly improved through modeling.
• This review serves as a reference for optimizing ocular therapies.