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Indications and outcomes of pediatric high flow nasal cannula use in the home setting
David D'Arienzo1,2,3, Liam Sanvido4, Reshma Amin5,6
1Complex Care Program, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Insights
Home high flow nasal cannula (HFNC) use is increasing in pediatric patients for various respiratory issues. This therapy shows few complications but may require escalation to other support methods.
Area of Science:
- Pediatric Respiratory Medicine
- Medical Technology Adoption
Background:
- Home high flow nasal cannula (HFNC) is an emerging respiratory support therapy for children.
- Understanding its use, indications, and outcomes is crucial for clinical practice.
Purpose of the Study:
- To describe patient characteristics and clinical outcomes of home HFNC in pediatrics.
- To evaluate trends in home HFNC initiation from 2013 to 2022.
Main Methods:
- Retrospective review of pediatric patients on home HFNC (2013-2023) at a Canadian tertiary hospital.
- Descriptive statistics and Mann-Kendall Trend test were used.
Main Results:
- 35 pediatric patients initiated on home HFNC between 2013-2023.
- Initiation significantly increased from 2013-2016 to 2021-2022 (p < .001).
- Common indications included airway obstruction, CO2 retention, and secretion clearance, often in children with genetic disorders and prior feeding tube use.
Conclusions:
- Home HFNC use is rising in pediatric care for diverse indications.
- The therapy appears safe with rare complications, though escalation to CPAP/BiPAP may be needed.
Objective:
To describe the patient characteristics, indications, and clinical outcomes of home high flow nasal cannula (HFNC) among pediatric patients. To evaluate secular trends in home HFNC initiation between 2013 and 2022.
Methods:
A retrospective review of all children on home HFNC between 2013 and 2023 was conducted at a tertiary care pediatric hospital in Ontario, Canada. Descriptive statistics were used to summarize results and identify indications for home HFNC initiation. Mann-Kendall Trend test was used to assess trends in HHF initiation between 2013 and 2022.
Results:
A total of 35 patients, ages 6 months-14 years old, were started on home HFNC between 2013 and 2023. HFNC initiation increased over time, from 0 patients in 2013-2016 to nine patients per year in 2021 and 2022 (p < .001). Home HFNC was almost exclusively prescribed for children with multisystem conditions, 77% with an underlying genetic disorder, and 77% with prior home feeding tube use. Most children (83%) had multiple indications leading to initiation of home HFNC. The main indications included the following: (i) upper airway obstruction (66%), (ii) clearance of retained CO2 (57%), (iii) increased work of breathing without sleep-disordered breathing (29%), (iv) promotion of secretion clearance/plastic bronchitis (29%), and (v) palliative care (14%). In addition, 37% did not tolerate a previous trial of Continuous/Bi-Level Positive Airway Pressure. Complications were rare, with only two children developing epistaxis requiring an emergency department visit and 4 children requiring escalation in home respiratory support to CPAP or BiPAP.
Conclusion:
HFNC is increasingly being initiated among children in the home setting for varied indications. Preliminary data suggests few complications and a need for escalation of therapy with home HFNC.
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