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Updated: Jun 4, 2025

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
[Neurochemical mechanisms of tremor in Parkinson's disease]
I A Putyatin1, N V Titova1,2
1Pirogov Russian National Research Medical University (Pirogovsky University), Moscow, Russia.
Abstract:
Tremor is one of the main motor symptoms of Parkinson's disease, and its pathophysiology remains largely unknown. The clinical and pathomorphological heterogeneity of tremor and the not always response to therapy complicate the task of researchers and clinicians. This review discusses the specific degeneration of neurotransmitter systems driving the development of tremor, and the influence of neurotransmitters on specific anatomical entities according to current models explaining tremor. It is discusses how changes in neurotransmitter systems may influence the clinical diversity of tremor and differences in response to therapy. Data from clinical trials demonstrating the effect of the dopamine receptor agonist piribedil on tremor are presented.
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