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Factors associated with accelerated parenteral weaning in children with intestinal failure: A descriptive cohort

Hadar Moran-Lev1,2, Samuel A Kocoshis1, Isabel Córdova Amador1

  • 1Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA.

JPEN. Journal of Parenteral and Enteral Nutrition
|December 18, 2024
PubMed

Insights

Children on long-term parenteral nutrition (PN) have shorter bowel length and increased risk of feeding aversion. Factors like bowel length and infections influence PN duration in pediatric intestinal rehabilitation.

Area of Science:

  • Pediatric Gastroenterology
  • Intestinal Rehabilitation
  • Parenteral Nutrition

Background:

  • Intestinal rehabilitation aims to wean children from parenteral nutrition (PN).
  • Identifying factors for accelerated weaning and long-term PN outcomes is crucial.

Purpose of the Study:

  • To identify factors associated with accelerated weaning from PN in children.
  • To evaluate long-term outcomes for children on chronic PN.

Main Methods:

  • Retrospective study at a pediatric Intestinal Rehabilitation Center.
  • Compared outcomes of children receiving long-term PN (>2 years) versus short-term PN (<2 years).

Main Results:

  • Long-term PN group had shorter small bowel (20% vs 60%) and colon (75% vs 100%).
  • Enteral feed initiation was delayed in the long-term PN group (71 vs 32.5 days).
  • Long-term PN associated with more central line-associated bloodstream infections (CLABSI) and higher feeding aversion (36% vs 0%).

Conclusions:

  • Small bowel/colon length, enteral feeding, and CLABSI frequency impact PN duration.
  • Long-term PN increases the risk of food aversion in children.
Abstract

Keywords:
parenteral nutritionshort bowelweaning

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