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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Associations between multimorbidity and kidney function decline in old age: A population-based cohort study.
Giorgi Beridze1, Lu Dai1, Juan-Jesús Carrero2
1Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Journal of the American Geriatrics Society
|December 18, 2024
Summary
Multimorbidity, the presence of multiple chronic conditions, significantly accelerates kidney function decline in older adults. Cardiometabolic multimorbidity poses a particularly high risk, underscoring the need for targeted interventions.
Area of Science:
- Gerontology
- Nephrology
- Epidemiology
Background:
- Chronic conditions impact kidney function.
- The role of multimorbidity and its patterns in kidney function decline is not well understood.
Purpose of the Study:
- To investigate the association between multimorbidity, its patterns, and kidney function decline in older adults.
- To identify specific multimorbidity patterns associated with accelerated decline in estimated glomerular filtration rate (eGFR).
Main Methods:
- Longitudinal study of 3094 older adults over 15 years.
- Multimorbidity assessed by number of conditions and latent class analysis (LCA) identified patterns.
- Joint and Cox regression models analyzed associations with eGFR changes.
Main Results:
- 87% of participants had multimorbidity.
- A dose-response relationship observed between number of conditions and eGFR decline.
- Cardiometabolic and high burden patterns significantly accelerated eGFR decline; cognitive/sensory pattern showed relative decline.
Conclusions:
- Multimorbidity is a significant risk factor for accelerated kidney function decline in older age.
- Cardiometabolic multimorbidity presents a particularly elevated risk for kidney function loss.
- Monitoring and interventions for high-risk multimorbidity patterns are crucial for preserving kidney function and reducing cardiovascular risk.
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