Follicular Lymphoma Presenting as a Primary Omental Mass: A Case Report and Pathological Analysis

Follicular lymphoma (FL) is a gradually progressing type of B-cell non-Hodgkin lymphoma (NHL), distinguished by its characteristic follicular pattern of growth and a typically indolent clinical course. It is identified by the abnormal growth of B-cells in the lymph nodes. We report a case of a 45-year-old female who came up with complaints of heavy menstrual bleeding and easy fatiguability. Imaging studies revealed an accidental finding of a primary mesenteric mass. Infracolic omentectomy and a bilateral pelvic lymph node dissection were done, and the specimen was sent for histopathological examination. Microscopic examination of the omental mass revealed a nodular growth pattern with prominent follicular structures composed of centrocytes and scattered centroblasts. Immunohistochemical staining demonstrated positivity for cluster of differentiation 20 (CD20), CD10, and B-cell lymphoma 2 (BCL2), confirming the diagnosis of FL. Thus, we report this rare manifestation of FL presenting as an isolated omental mass.