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Extramedullary disease in Waldenström macroglobulinemia: A population-based observational study
Simon Østergaard1,2, Lars Munksgaard2,3, Torsten Holm Nielsen3,4,5
1Department of Pathology Zealand University Hospital Roskilde Denmark.
Introduction:
Extramedullary disease (EMD) is a rare manifestation of Waldenström macroglobulinemia (WM), and its clinical and prognostic implications are poorly understood.
Methods:
In this single-center study, we investigated the clinical significance of EMD in a cohort of 469 WM patients.
Results:
EMD was identified in 30 (6.4%) patients, with the central nervous system, kidneys, and lungs being the most frequently affected sites. The cumulative incidence of EMD was 12.6% at 15 years. Median overall survival rates at 5 and 10 years for patients with EMD were 63% and 37%, respectively.
Conclusion:
Our findings indicate a persistent risk of EMD throughout the disease course, with no significant impact on long-term survival.
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