Research progress on the relationship between traumatic brain injury and brain-gut-microbial axis

Area of Science:

• Neuroscience
• Microbiology
• Gastroenterology

Background:

• Traumatic brain injury (TBI) is a major cause of death and disability.
• The brain-gut-microbial (BGM) axis, a communication network between the brain and gut, is increasingly recognized for its role in neurological disorders.

Purpose of the Study:

• To comprehensively explore the intricate relationship between the BGM axis and TBI.
• To review the physiological effects, pathophysiology, and potential therapeutic interventions related to the BGM axis in TBI.

Main Methods:

• Literature review and synthesis of existing research on the BGM axis and TBI.
• Analysis of bidirectional communication pathways within the BGM axis relevant to TBI.

Main Results:

• The BGM axis plays a critical role in the pathophysiology of TBI.
• Bidirectional regulatory pathways of the BGM axis present novel therapeutic targets for TBI.

Conclusions:

• The BGM axis offers promising avenues for developing innovative clinical treatments for TBI.
• Further research is essential to translate BGM axis understanding into effective TBI therapies.