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Published on: March 31, 2019
CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ
Juan Tang1,2, Donglin Yu1,2, Jiaojiao Song3
1Department of Oral and Maxillofacial Surgery, Binzhou Medical University Hospital, Binzhou, China.
Introduction:
Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal malignancy, accounting for 95% of head and neck cancers. Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein ZETA (14-3-3ζ) is central to various signalling pathways and is pivotal in tumour progression.
Methods:
Cancerous and corresponding non-cancerous tissue samples were collected from five patients diagnosed with HNSCC. circRNA and mRNA expression profiles were analyzed using high-throughput sequencing techniques. Potential circRNA-microRNA (miRNA)-mRNA interactions were predicted using bioinformatics tools.
Results:
The study found that CircRNA_036186 regulates the expression of 14-3-3ζ in HNSCC through miR-193b-5p.
Discussion:
These findings suggest that CircRNA_036186 has the potential to be a biomarker and therapeutic target for HNSCC and provide some theoretical basis for further research on the role of circRNA in HNSCC.
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