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Excessive Daytime Sleepiness as a Risk Factor for Impulse Control Disorders in Parkinson's Disease

  • 0Department of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Neuropsychiatric Disease and Treatment +

|

December 18, 2024

|

December 18, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Excessive daytime sleepiness (EDS) is a significant risk factor for developing impulse control disorders (ICDs) in Parkinson

Area Of Science

  • Neurology
  • Sleep Medicine
  • Movement Disorders

Background

  • Impulse control disorders (ICDs) and excessive daytime sleepiness (EDS) are prevalent in Parkinson's disease (PD).
  • Longitudinal data on the association between EDS and ICDs in PD patients are limited.
  • Understanding this relationship is crucial for managing PD symptoms.

Purpose Of The Study

  • To investigate the longitudinal association between excessive daytime sleepiness (EDS) and impulse control disorders (ICDs) in Parkinson's disease (PD).
  • To identify risk factors for ICD development in PD patients experiencing EDS.

Main Methods

  • A longitudinal study involving 260 Parkinson's disease (PD) patients from the Parkinson's Progression Markers Initiative.
  • Patients were followed for up to 4 years to monitor the onset of ICDs.
  • Univariable and multivariable logistic regression analyses were employed to assess the association between EDS and ICDs.

Main Results

  • The incidence of ICDs was 23.8% (62 patients) at the 4-year follow-up.
  • Patients who developed ICDs had significantly higher Epworth Sleepiness Scale (ESS) scores and a higher proportion of EDS.
  • Multivariable analysis revealed that high ESS scores (OR=2.01), high dopamine agonist doses (OR=2.54), high Geriatric Depression Scale scores (OR=2.33), and postural instability (OR=3.03) were associated with ICD occurrence.

Conclusions

  • Excessive daytime sleepiness (EDS) is identified as a risk factor for the development of impulse control disorders (ICDs) in Parkinson's disease (PD).
  • Clinical attention to EDS in PD patients may aid in the early detection and management of ICDs.
  • This finding offers a potential new avenue for understanding and treating ICDs in the context of PD.

Keywords:

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