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Published on: November 23, 2014
Antiangiogenic therapy exerts antitumor effects by altering the tumor microenvironment: bibliometric analysis
Yuan Kang1, Yixin Kang1, Dianbao Zhang1
1The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Background:
Antiangiogenic therapy can alter the tumor microenvironment (TME) and thus exert anti-tumor effects, and has the potential to increase the efficacy of conventional therapy and immunotherapy. The aim of this study was to examine current research hotspots and collaborative networks on the relationship between previous antiangiogenic therapies and the TME through bibliometric analysis.
Method:
From the Web of Science Core Collection database, all publications from inception through December 2023 were downloaded. In-depth analysis was performed by Bibliometrix packages in R. Keywords and collaborative networks were analyzed using VOSviewers and Citespace.
Result:
We obtained a total of 9027 publications. They come from 27 countries and were published in 1387 journals, with a total of 39,604 authors in the studied area. The number of publications increases dramatically from 2014 to 2023, accounting for 73.87% (6668/9027) of all publications. China and CANCERS have the highest number of publications on this topic and CANCER RESEACH is the most influential. In the last decade (2013- 2023), research has gradually shifted from studying the role of vascular endothelial growth factor in the TME to examining how antivascular therapy can contribute to the progression of cancer treatment. Furthermore, nanoparticle-based drug delivery systems and immunotherapy have been widely explored in the past five years. The findings of this study will help scientists to explore this promising field in depth by providing insight into the relationship between antiangiogenic therapy and the TME.
Conclusion:
The relationship between the antiangiogenic therapy and the TME has been developing rapidly, but cooperation between different institutions and countries is still limited. Researchers can use this study to identify hotspots and develop trends for related research, thereby facilitating the development and cooperative exchange in this field, as well as to suggest potential future research directions.
Insights
Antiangiogenic therapy impacts the tumor microenvironment (TME) to fight cancer. This bibliometric analysis reveals research trends and collaboration gaps in antiangiogenic therapy and TME interactions.
Area of Science:
- Oncology
- Cancer Research
- Immunotherapy
Background:
- Antiangiogenic therapy modulates the tumor microenvironment (TME), offering anti-tumor effects.
- It holds potential for enhancing conventional and immunotherapy efficacy.
- Understanding the antiangiogenic therapy-TME relationship is crucial for cancer treatment advancement.
Purpose of the Study:
- To conduct a bibliometric analysis of research on antiangiogenic therapies and the TME.
- To identify current research hotspots and collaborative networks in this field.
- To provide insights for future research directions and facilitate scientific exchange.
Main Methods:
- Bibliometric analysis of publications from the Web of Science Core Collection (inception-December 2023).
- Utilized Bibliometrix packages in R for in-depth analysis.
- Employed VOSviewers and Citespace for keyword and collaborative network analysis.
Main Results:
- A total of 9027 publications were analyzed, originating from 27 countries and 1387 journals.
- Research output surged from 2014-2023 (73.87%), with China leading in publications.
- Key research shifts include focus on vascular endothelial growth factor, antivascular therapy, nanoparticle delivery systems, and immunotherapy.
Conclusions:
- The field of antiangiogenic therapy and TME interactions is rapidly evolving.
- Limited international and institutional collaboration exists.
- This study offers insights into research trends, hotspots, and collaboration opportunities to advance the field.
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