Elevated uric acid level and metabolic syndrome in Non-Hispanic Black American adults

To ascertain the direct and indirect link between elevated uric acid (eUA) and metabolic syndrome (MetSyn) in Non-Hispanic Black (NHB) American adults.

Structural equation modeling (SEM) was used to disentangle the U.S. National Health and Nutritional Examination Survey (2015-2018 NHANES) dataset and investigate the connection between eUA and components of MetSyn as per the criteria from the National Cholesterol Education Program (NCEP) Adult Treatment Panel III. The association between eUA and MetSyn was determined using odds ratios from sex-specific multivariable logistic regression analysis. The analysis was adjusted for age, physical activity, alcohol use, and smoking. SEM coefficients were used to measure the strength of the link between eUA and MetSyn components.

NHB American men with eUA had 1.41-fold greater odds of MetSyn, and NHB American women with eUA had 2.70-fold greater odds of MetSyn after adjusting for confounding factors. Elevated uric acid was more strongly and directly linked to abdominal obesity (β = 0.320, p < 0.01) in NHB American men, and with abdominal obesity (β = 0.423, p < 0.01), dyslipidemia (β = 0.151, p < 0.01) and hypertension (β = 0.121, p < 0.01) in NHB American women than between eUA and other components of MetSyn.

This study's finding linking eUA to MetSyn components in NHB American adults needs reaffirmation through a robust prospective study design. If validated, eUA could help predict and prevent MetSyn in NHB American adults.