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Wilms' Tumor - An Audit
Yogesh Kumar Sarin1, Pute U Losu1, Anita Nangia2
1Department of Pediatric Surgery, Lady Hardinge Medical College and Associated Kalawati Children's Hospital, New Delhi, India.
Journal of Indian Association of Pediatric Surgeons
|December 18, 2024
Summary
This study analyzed outcomes for 23 children with Wilms
Area of Science:
- Pediatric Oncology
- Nephrology
- Surgical Oncology
Background:
- Wilms' tumor (WT) is a rare kidney cancer primarily affecting children.
- Understanding treatment outcomes is crucial for improving patient management.
- The International Society of Paediatric Oncology (SIOP) provides standardized protocols for WT management.
Purpose of the Study:
- To analyze the outcomes of pediatric patients diagnosed with Wilms' tumor.
- To evaluate the effectiveness of the SIOP Umbrella protocol in a clinical setting.
- To identify factors influencing treatment success and survival rates.
Main Methods:
- Retrospective analysis of 23 children with WT managed by a single surgeon from 2021 to 2024.
- Utilized the SIOP Umbrella protocol for patient management.
- Data collected included patient demographics, tumor characteristics, treatment modalities, and survival outcomes.
Main Results:
- Median age at presentation was 36 months, with variations between unilateral (uWT) and bilateral (bWT) cases.
- Tumor volume changes were monitored post-neoadjuvant chemotherapy (NACT), with variable responses observed.
- Surgical interventions included nephroureterectomy and nephron-sparing surgery. Overall staging revealed intermediate and high-risk groups.
- 1-year overall survival was 84% and event-free survival was 76%.
Conclusions:
- The study reports excellent short-term outcomes for localized Wilms' tumor.
- These results are from a center in a low-middle-income country, highlighting the feasibility of standardized protocols.
- Further research may focus on long-term outcomes and specific challenges in resource-limited settings.
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