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Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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Vasoactive Intestinal Polypeptide Secreting MS Neuroblastoma.

Josy Thomas1, Nitin James Peters1, Aravind Sekar2

  • 1Department of Pediatric Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Journal of Indian Association of Pediatric Surgeons
|December 18, 2024
PubMed
Summary
This summary is machine-generated.

A rare case of a child with neuroblastoma experienced chronic diarrhea due to high vasoactive intestinal peptide (VIP) levels. Tumor removal successfully lowered VIP and resolved the diarrhea, highlighting a unique clinical presentation.

Keywords:
Chronic diarrheaMS neuroblastomaVIPomavasoactive intestinal peptide

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Area of Science:

  • Pediatric Oncology
  • Endocrinology

Background:

  • Neuroblastoma is a common pediatric malignancy.
  • Vasoactive intestinal peptide (VIP) secreting tumors are rare, particularly in conjunction with neuroblastoma.

Observation:

  • A 17-month-old child presented with MS-stage neuroblastoma and chronic diarrhea.
  • Elevated serum VIP levels were identified as the cause of the persistent diarrhea.

Findings:

  • This case represents the first reported instance of a VIP-secreting tumor co-occurring with MS-stage neuroblastoma.
  • Surgical excision of the tumor led to a substantial decrease in VIP levels.
  • The patient's chronic diarrhea resolved post-operatively.

Implications:

  • This case expands the understanding of rare neuroblastoma presentations and paraneoplastic syndromes.
  • Highlights the importance of considering VIP-secreting tumors in pediatric patients with neuroblastoma and unexplained diarrhea.
  • Suggests surgical intervention as an effective treatment for VIP-induced diarrhea in this context.