Vasoactive Intestinal Polypeptide Secreting MS Neuroblastoma

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Immunostaining to Visualize Murine Enteric Nervous System Development
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Immunostaining to Visualize Murine Enteric Nervous System Development

Published on: April 29, 2015

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Josy Thomas1, Nitin James Peters1, Aravind Sekar2

  • 1Department of Pediatric Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Journal of Indian Association of Pediatric Surgeons
|December 18, 2024
PubMed

Keywords:
Chronic diarrheaMS neuroblastomaVIPomavasoactive intestinal peptide

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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