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Vasoactive Intestinal Polypeptide Secreting MS Neuroblastoma.
Josy Thomas1, Nitin James Peters1, Aravind Sekar2
1Department of Pediatric Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
A rare case of a child with neuroblastoma experienced chronic diarrhea due to high vasoactive intestinal peptide (VIP) levels. Tumor removal successfully lowered VIP and resolved the diarrhea, highlighting a unique clinical presentation.
Area of Science:
- Pediatric Oncology
- Endocrinology
Background:
- Neuroblastoma is a common pediatric malignancy.
- Vasoactive intestinal peptide (VIP) secreting tumors are rare, particularly in conjunction with neuroblastoma.
Observation:
- A 17-month-old child presented with MS-stage neuroblastoma and chronic diarrhea.
- Elevated serum VIP levels were identified as the cause of the persistent diarrhea.
Findings:
- This case represents the first reported instance of a VIP-secreting tumor co-occurring with MS-stage neuroblastoma.
- Surgical excision of the tumor led to a substantial decrease in VIP levels.
- The patient's chronic diarrhea resolved post-operatively.
Implications:
- This case expands the understanding of rare neuroblastoma presentations and paraneoplastic syndromes.
- Highlights the importance of considering VIP-secreting tumors in pediatric patients with neuroblastoma and unexplained diarrhea.
- Suggests surgical intervention as an effective treatment for VIP-induced diarrhea in this context.
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