Phase angle as a prognostic factor in patients with cancer: a systematic review of the existing evidence via a meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Phase angle (PA), a measure of cell health, is a significant prognostic marker for cancer survival. Lower PA values correlate with a 27% decreased likelihood of survival, regardless of cancer type or treatment.
Area Of Science
- Oncology
- Biophysics
- Bioelectrical Impedance Analysis
Background
- Phase angle (PA) is derived from bioelectrical impedance analysis (BIA).
- PA reflects cell membrane health, integrity, hydration, and nutritional status.
- Previous associations between PA and cancer survival have been inconsistent.
Purpose Of The Study
- To evaluate the prognostic role of PA in cancer patient survival.
- To clarify the utility of PA as a predictive biomarker in oncology.
Main Methods
- A systematic literature search was conducted on PubMed and EMBASE up to December 2023.
- A meta-analysis of relevant studies was performed.
- Included 30 studies with 6587 participants.
Main Results
- Phase angle (PA) demonstrated a significant prognostic role in cancer patient survival (HR = 0.73; 95% CI, 0.66-0.81).
- Patients with lower PA values had a 27% reduced likelihood of survival.
- Subgroup analyses confirmed PA's prognostic value across different geographical populations, cancer types, and treatment modalities.
Conclusions
- Phase angle (PA) shows potential as a non-invasive and cost-effective prognostic tool in oncological care.
- PA can aid in assessing patient outcomes and guiding treatment strategies.
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