Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Quantitative molecular breast imaging for early prediction of neoadjuvant systemic therapy response in locally advanced breast cancer patients.

Clinical imaging·2026

Same author

Risk of malignancy after diagnosis of radial sclerosing lesion without atypia.

Breast cancer research and treatment·2026

Same author

Non-BRCA germline pathogenic variants and response to neoadjuvant systemic therapy in triple-negative breast cancer patients enrolled in a prospective clinical trial.

Breast cancer research and treatment·2026

Same author

Erratum: Imaging- and Tumor Biomarker-Based Multivariable Model for Early Prediction of Pathologic Complete Response to Neoadjuvant Systemic Therapy in Triple-Negative Breast Cancer.

JCO precision oncology·2026

Same author

Definitive, stereotactic ablative radiotherapy and endocrine therapy without surgery for select low-risk breast cancers: A prospective, phase II trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026

Same author

The ARTEMIS trial identifies immune activation as a key predictor of neoadjuvant chemotherapy response in triple-negative breast cancer.

Breast cancer research : BCR·2026

Same journal

Breast Cancer Risk and Screening in Active Duty Military Members and Veterans.

Journal of breast imaging·2026

Same journal

Correction to: Prevalence of Axillary Arch Variant Anatomy on Breast MRI and Impact on Axillary Lymph Node Assessment.

Journal of breast imaging·2026

Same journal

Breast Arterial Calcification on Mammography: Act Now Please.

Journal of breast imaging·2026

Same journal

Breast Arterial Calcification as a Predictor for Future Cardiovascular Events and Mortality: A Systematic Review and Meta-analysis.

Journal of breast imaging·2026

Same journal

Imaging Features and Risk Factors Associated with Locoregional Recurrence of Breast Cancer: Insights for Imaging and Clinical Practice.

Journal of breast imaging·2026

Same journal

A Framework for Aligning 5-Year and Lifetime Breast Cancer Risk in Women Without High-Penetrance Mutations.

Journal of breast imaging·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 4, 2025

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

Published on: August 14, 2012

Current Concepts in Molecular Breast Imaging.

Miral M Patel¹, Beatriz E Adrada¹, Mary S Guirguis¹

¹Department of Breast Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Journal of Breast Imaging

|December 18, 2024

Summary

This summary is machine-generated.

Molecular breast imaging (MBI) offers functional insights into breast tumors using a radiotracer. This technique aids in screening dense breasts, diagnosis, staging, and treatment response evaluation.

Keywords:

Tc-99m sestamibi breast cancer screening breast cancer staging breast-specific gamma imaging molecular breast imaging

More Related Videos

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Published on: September 19, 2014

Related Experiment Videos

Last Updated: Jun 4, 2025

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

Published on: August 14, 2012

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Published on: September 19, 2014

Area of Science:

Radiology and Nuclear Medicine
Oncology
Medical Imaging

Background:

Molecular breast imaging (MBI) is a functional imaging technique.
It uses technetium 99m sestamibi radiotracer uptake to assess breast tumor biology.
MBI serves as a valuable tool in various clinical scenarios.

Purpose of the Study:

To review the equipment, procedures, and standardized lexicon for Molecular Breast Imaging (MBI).
To outline the clinical indications for utilizing MBI.
To discuss the radiation dose associated with MBI procedures.

Main Methods:

Review of existing literature and clinical guidelines on Molecular Breast Imaging.
Description of MBI equipment and standardized reporting lexicon (BI-RADS).
Analysis of clinical applications and radiation dosimetry.

Main Results:

MBI is effective for supplemental screening in women with dense breasts.
It aids in breast cancer diagnosis, staging, and monitoring neoadjuvant therapy response.
MBI is useful for problem-solving when other imaging is inconclusive and for patients ineligible for MRI.

Conclusions:

Molecular breast imaging is a versatile functional imaging modality with established clinical roles.
A standardized lexicon improves MBI reporting accuracy.
Understanding MBI procedures, indications, and radiation dose is crucial for its effective implementation.