Continuous Biosensing to Monitor Acute Systemic Inflammation, a Diagnostic Need for Therapeutic Guidance

Area of Science:

• Biomedical Engineering
• Clinical Diagnostics
• Translational Medicine

Background:

• Acute inflammation poses significant challenges in managing critically ill patients, necessitating improved monitoring strategies.
• Current methods for tracking acute inflammation lack the continuous data needed for timely therapeutic adjustments.
• Continuous biosensing technologies present a potential solution for real-time patient status assessment.

Purpose of the Study:

• To review the medical need for continuous monitoring in acute inflammatory diseases.
• To explore the potential of continuous biosensing technologies for inflammation biomarker detection.
• To identify challenges and future directions for clinical implementation of these biosensors.

Main Methods:

• Discussion of theoretical and empirical data on inflammation biomarkers.
• Review of current state-of-the-art sensing strategies for continuous monitoring.
• Analysis of challenges associated with nanoswitch-based biosensors and bioreceptor development.

Main Results:

• Nanoswitch biosensors offer high measurement frequencies but require enhanced sensitivity and reliability.
• Bioreceptor development, regeneration techniques, and sample pretreatment are critical areas for advancement.
• Clinical translation requires overcoming technical hurdles and fostering interdisciplinary collaboration.

Conclusions:

• Continuous biosensing holds significant potential for guiding therapeutic interventions in acute inflammation.
• Key challenges include improving sensor sensitivity, reliability, and integration into clinical workflows.
• Successful implementation necessitates collaboration among clinicians, scientists, engineers, and regulatory bodies.