Meroterpenoids from Rhododendron racemosum and their anti-inflammatory activities
Si-Xuan Liu1, Si-Yang Dai1, Yong-Fu Lu1
1Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150086, China.
Abstract:
Three meroterpenoids, including one new compound, ranhuadujuanine E (1), one new natural product, methyl (E)-3-(3,7-dimethylocta-2,6-dien-1-yl)-2,4-dihydroxy-6-methylbenzoate (2), and one known compound, ranhuadujuanine D (3), along with two known sesquiterpenoids (4-5) were isolated from Rhododendron racemosum. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of C-6' in compound 1 was assigned by using Snatzke's method. Compounds 1-3 had inhibitory effects on LPS-induced NO release in RAW264.7 cells.
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