Polyzwitterions: controlled synthesis, soft materials and applications

Polyzwitterions refer to polymers containing both positive and negative charged groups in one side chain, which have shown unique physicochemical properties and significant potential in diverse applications due to their amphiphilic and net-neutral charged properties. This review aims to highlight the recent advances in the design and synthesis of polyzwitterions including direct polymerization of zwitterionic monomers and deionization of polymers. Furthermore, the formation of polyzwitterion based soft materials such as nanoparticles by self-assembly, hydrogels, coatings and polyzwitterion brushes, as well as the influence of the microstructure on their properties and applications are discussed. The potential applications of polyzwitterions in drug delivery, antifouling, lubrication, energy storage and antibacterial are also summarized. Finally, the prospects of polyzwitterions are proposed.