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Related Experiment Video

Updated: Jun 4, 2025

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
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Dynamic 18 F-FDG PET to detect differences among patients with progressive and relapsing multiple sclerosis: a pilot

Carlos Quintanilla-Bordás1, Matías Fernández-Patón2, Amadeo Ten2

  • 1Neuroimmunology Unit, La Fe University and Polytechnic Hospital, Avda. Fernando Abril Martorell, 106, Valencia, 46026, Spain. carlosqb@gmail.com.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|December 18, 2024
PubMed
Summary

Dynamic 18-F-FDG PET-MRI shows potential differences in glucose metabolism between relapsing-remitting and secondary progressive multiple sclerosis (MS). This technique may offer a new radiological marker for MS progression.

Keywords:
18 F-FDG kinetic analysisGlucose metabolismMultiple sclerosisSecondary progressive multiple sclerosis

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Area of Science:

  • Neuroimaging
  • Nuclear Medicine
  • Biochemistry

Background:

  • Multiple Sclerosis (MS) presents as relapsing-remitting (RRMS) or secondary progressive (SPMS) forms.
  • Chronic inflammation and altered blood-brain barrier function in MS may impact glucose metabolism.
  • Positron emission tomography-magnetic resonance imaging (PET-MRI) with 2-deoxy-2(18F)fluoro-d-glucose (18F-FDG) assesses glucose metabolism but hasn't been studied in MS.

Purpose of the Study:

  • To investigate glucose distribution kinetics differences between long-standing SPMS and RRMS using dynamic 18F-FDG PET-MRI.
  • To explore the potential of dynamic 18F-FDG PET-MRI as a tool for understanding MS pathophysiology.

Main Methods:

  • Dynamic 18F-FDG PET-MRI scans were performed on 11 patients with long-standing MS (4 RRMS, 7 SPMS).
  • Kinetic analysis utilized a three-compartment model to calculate individual rate constants for 18F-FDG.
  • This method quantures glucose uptake and phosphorylation dynamics.

Main Results:

  • Patients with SPMS showed a trend towards increased net glucose influx rate (p=0.059).
  • SPMS patients also exhibited an increased rate constant for glucose phosphorylation.
  • These findings suggest heightened glucose uptake and glycolysis in SPMS.

Conclusions:

  • Dynamic 18F-FDG PET-MRI is a feasible method for in vivo glucose metabolism assessment in MS.
  • Preliminary results indicate a potential radiological marker for MS progression.
  • Further research is necessary to validate these findings and their clinical implications.