Transcriptomic analysis reveals potential crosstalk genes and immune relationship between triple-negative breast
Zhili Zhuo1, Wenping Lu2, Ling Zhang3
1Oncology Department, China Academy of Chinese Medical Sciences Guang'anmen Hospital, No.5 Beixiange, Xicheng District, Beijing, 100053, China.
Abstract:
TNBC, the most aggressive form of breast cancer, lacks accurate and effective therapeutic targets. Immunotherapy presents a promising approach for addressing TNBC. Anxiety and depression are frequently concurrent symptoms in TNBC patients. MDD affects the tumor immune microenvironment of TNBC, with its characteristic genes affecting the pathophysiology of MDD and potentially increasing the risk of TNBC recurrence and metastasis. This study reveals significant differences in T lymphocyte infiltration between high-risk and low-risk TNBC groups based on MDD feature genes. This finding aids in identifying TNBC patients who may benefit from immunotherapy, providing new insights for future TNBC immunotherapy strategies. Our aim is to identify MDD-related genes involved in the pathogenesis of TNBC and to provide predictive biomarkers for TNBC immunotherapy.
Insights
Major depressive disorder (MDD) impacts triple-negative breast cancer (TNBC) by altering its immune microenvironment. Identifying MDD genes may predict TNBC immunotherapy response and recurrence risk.
Area of Science:
- Oncology
- Immunology
- Psychiatry
Background:
- Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies.
- Immunotherapy offers a promising avenue for TNBC treatment.
- Major depressive disorder (MDD) frequently co-occurs in TNBC patients and influences the tumor immune microenvironment.
Purpose of the Study:
- To investigate the role of MDD-related genes in TNBC pathogenesis.
- To identify potential predictive biomarkers for TNBC immunotherapy.
- To explore the relationship between MDD and T lymphocyte infiltration in TNBC.
Main Methods:
- Analysis of MDD feature genes in TNBC patient cohorts.
- Assessment of T lymphocyte infiltration levels in relation to MDD gene expression.
- Identification of key genes linking MDD and TNBC pathophysiology.
Main Results:
- Significant differences in T lymphocyte infiltration were observed between high-risk and low-risk TNBC groups stratified by MDD feature genes.
- MDD-related genes were found to influence the tumor immune microenvironment in TNBC.
- Specific MDD genes correlate with TNBC recurrence and metastasis risk.
Conclusions:
- MDD-related genes serve as potential biomarkers for predicting immunotherapy efficacy in TNBC.
- Understanding the interplay between MDD and TNBC immunity can inform novel immunotherapy strategies.
- Targeting MDD-associated pathways may improve outcomes for TNBC patients.
