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SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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Unlocking the Potential of Senolytic Compounds: Advancements, Opportunities, and Challenges in Ageing-Related

Lilian Sales Gomez1,2, Diana Jurk3,4

  • 1Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.

Sub-Cellular Biochemistry
|December 18, 2024
PubMed

Insights

Cellular senescence contributes to aging. Researchers are developing senolytics, drugs that selectively kill senescent cells, to combat age-related diseases with promising preclinical results.

Area of Science:

  • Gerontology and Cellular Biology
  • Pharmacology and Drug Discovery

Background:

  • Cellular senescence is a key factor in aging and age-related diseases.
  • Identifying compounds that selectively eliminate senescent cells (senolytics) is a major research focus.

Purpose of the Study:

  • To review recent advancements in senolytic drug research.
  • To cover basic science, preclinical, and clinical investigations of senolytics.
  • To discuss the potential and challenges of senolytic interventions.

Main Methods:

  • Literature review of recent senolytic research.
  • Analysis of preclinical and clinical study findings.
  • Identification of emerging senolytic compounds and strategies.

Main Results:

  • Over 40 compounds show senolytic activity in preclinical studies.
  • Senolytics demonstrate potential for reversing or improving age-related conditions.
  • Encouraging results have been observed in various age-related intervention studies.

Conclusions:

  • Senolytic drug development is a rapidly advancing field with significant therapeutic potential.
  • Further research is needed to address challenges and optimize senolytic therapies for clinical use.
  • Senolytics offer a promising avenue for combating age-related diseases and promoting healthy aging.
Keywords:
Age-related diseasesAgeingCellular senescenceSenolytic

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