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IgD in human colostrum.

M A Keller, D C Heiner, A S Myers

    Pediatric Research
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Immunoglobulin D (IgD) levels in colostrum suggest localized antibody production in the mammary gland, particularly against environmental allergens like Bermuda grass. IgD

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    Area of Science:

    • Immunology
    • Maternal-fetal medicine
    • Biochemistry

    Background:

    • Immunoglobulin D (IgD) is present in human colostrum and plasma.
    • The role and transport mechanisms of IgD in breast milk are not fully understood.
    • Investigating specific IgD antibodies can provide insights into local immune responses.

    Purpose of the Study:

    • To quantify total and specific IgD antibodies in colostrum and plasma.
    • To compare the colostrum-to-plasma (C/P) ratios of IgD with IgG and albumin.
    • To explore potential localized antibody enhancement in the mammary gland.

    Main Methods:

    • Simultaneous colostrum and plasma samples were collected from postpartum women.
    • Solid-phase radioimmunoassay was used to measure total and specific IgD antibodies.

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  • Statistical analysis, including correlation coefficients, was performed on C/P ratios.

    • Main Results:

    • Geometric mean concentrations of IgD were higher in plasma than in colostrum.
    • Six subjects showed enhanced specific IgD antibody C/P ratios, suggesting local production.
    • IgD C/P ratios in colostrum exceeded those of IgG and albumin, indicating different transport.

    Conclusions:

    • Data suggest a distinct mechanism for IgD entry into milk compared to IgG or albumin.
    • Localized enhancement of IgD antibodies in colostrum may occur, especially against Bermuda grass.
    • Further research is needed to elucidate the specific functions of IgD in neonatal immunity.