Cumulative deficits frailty index and relationship status predict survival in multiple myeloma
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View abstract on PubMed
Summary
This summary is machine-generated.Frailty, assessed by a cumulative deficit index, significantly impacts survival and symptom burden in newly diagnosed multiple myeloma (MM). Non-married status also affects outcomes, highlighting the need to reassess frailty and social support during treatment.
Area Of Science
- Hematology
- Gerontology
- Oncology
Background
- Assessing frailty in multiple myeloma (MM) often relies on clinical trial data, with limited information on patient-reported outcomes and social determinants of health.
- The prognostic value of frailty and socioeconomic status (SES) in newly diagnosed MM patients in real-world settings requires further investigation.
Purpose Of The Study
- To evaluate the prognostic impact of the cumulative deficit frailty index (FI) and relationship/socioeconomic status (SES) in newly diagnosed MM patients.
- To examine the association between frailty and patient-reported outcomes, including symptom burden and quality of life.
Main Methods
- Retrospective study of 515 newly diagnosed MM patients (2005-2018) at Mayo Clinic.
- Cumulative deficit frailty index (FI) calculated using activities of daily living and comorbidity data.
- Frailty defined as FI ≥0.15; analysis of associations with disease stage, transplantation, survival, and patient-reported outcomes.
Main Results
- Frailty (39% of patients) and non-married status were linked to higher disease stage, reduced early transplantation likelihood, and independently decreased survival.
- Frail patients reported worse fatigue, pain, and quality of life scores.
- Frailty status was dynamic, with ~25% deteriorating and <10% improving within 3-12 months; SES was not independently associated with survival.
Conclusions
- A cumulative deficit FI effectively identifies higher symptom burden and decreased survival in a real-world MM cohort.
- Frailty is dynamic and requires reassessment during treatment; social support is a valuable prognostic indicator for clinical evaluation.
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