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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Is the Otolithic Function Affected in Patients with Obstructive Sleep Apnea Syndrome?
Merve Ozses1, Serpil Mungan Durankaya2, Enis A Guneri3
1Department of Otorhinolaryngology, Audiology Programme, Institute of Health Sciences, Dokuz Eylul University, İzmir, Türkiye.
Obstructive sleep apnea syndrome (OSAS) significantly impacts vestibular function, indicated by reduced vestibular-evoked myogenic potential (VEMP) responses. This suggests hypoxia affects balance and daily activities in OSAS patients, necessitating targeted rehabilitation.
Area of Science:
- Neuroscience
- Otolaryngology
- Sleep Medicine
Background:
- Obstructive sleep apnea syndrome (OSAS) is linked to cardiovascular and neurological issues.
- The neuro-otological effects of OSAS-induced hypoxia are not fully understood.
- Vestibular and audiological tests assess brainstem neuronal degeneration from recurrent hypoxia.
Purpose of the Study:
- To evaluate vestibular-evoked myogenic potential (VEMP) test findings in OSAS patients.
- To detect hypoxia's influence on the vestibular reflex arc in OSAS.
- To correlate VEMP results with Activity-Specific Balance Confidence (ABC) and Berg Balance Scale (BBS) scores.
Main Methods:
- Cross-sectional study involving 40 participants (20 OSAS, 20 controls) aged 18-60.
- Polysomnography used for OSAS diagnosis.
- Cervical VEMP (cVEMP) and ocular VEMP (oVEMP) tests performed.
- Balance assessed using ABC and BBS scales.
Main Results:
- Significantly lower cVEMP (50%) and oVEMP (45%) response rates and amplitudes in the OSAS group.
- No significant differences in other VEMP parameters between groups.
- Statistically significant decrease in ABC and BBS scores among OSAS patients.
Conclusions:
- VEMP alterations in OSAS patients indicate adverse effects of hypoxia on vestibular reflex pathways.
- Hypoxia in OSAS may lead to neuro-otological deficits.
- ABC and BBS scores can inform personalized rehabilitation for OSAS patients.
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