A comprehensive dataset on cytotoxicity of ionic liquids

Area of Science:

• Green Chemistry
• Toxicology
• Materials Science

Background:

• Ionic liquids (ILs) are versatile, tunable salts with broad applications.
• The environmental and biological toxicity of ILs presents significant challenges.
• Understanding IL toxicity is crucial for safe application and development.

Purpose of the Study:

• To create a comprehensive dataset of ionic liquid cytotoxicity.
• To facilitate structure-activity relationship (SAR) studies for ILs.
• To identify key structural features influencing IL cytotoxicity.

Main Methods:

• Compiled data from 151 research papers.
• Included 1227 unique ionic liquids and 3837 data entries.
• Detailed experimental parameters such as incubation time, cell line, and assay.

Main Results:

• Established a large, publicly available dataset on IL cytotoxicity.
• Provided detailed information for each data entry including chemical identifiers and experimental conditions.
• The dataset covers a wide range of IL structures and their corresponding toxicity values.

Conclusions:

• The compiled dataset is a valuable resource for researchers studying IL toxicity.
• Enables in-depth SAR analysis to predict and mitigate IL toxicity.
• Promotes safer design and application of ionic liquids in various fields.