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Pediatric SARS-CoV-2 long term outcomes study (PECOS): cross sectional analysis at baseline

Gina A Montealegre Sanchez1, Lauren E Arrigoni2,3, Alexandra B Yonts3,4,5

  • 1Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA. montealegrega@nih.gov.

Pediatric Research
|December 18, 2024
PubMed

Insights

Children infected with SARS-CoV-2 reported more symptoms and worse quality of life compared to uninfected children. This ongoing study, Pediatric COVID-19 Conquer Study (PECOS), will track long-term effects of COVID-19 in pediatric populations.

Area of Science:

  • Pediatric infectious diseases
  • Longitudinal cohort studies
  • COVID-19 outcomes

Background:

  • The Pediatric COVID-19 Conquer Study (PECOS) investigates long-term outcomes of SARS-CoV-2 infection in children.
  • Characterizing post-COVID-19 conditions in pediatric populations is crucial for understanding disease impact.

Purpose of the Study:

  • To characterize long-term outcomes following pediatric SARS-CoV-2 infection.
  • To compare symptoms, functional status, and quality of life between infected and uninfected children.

Main Methods:

  • Cross-sectional analysis of infected and uninfected pediatric cohorts (0-21 years) at baseline.
  • Data collection included demographics, medical history, symptoms, physical exams, cardiopulmonary evaluations, and validated psychological/developmental surveys.
  • Primary outcomes involved comparing cohort abnormalities across all collected measures.

Main Results:

  • Infected participants (n=541) reported more constitutional, HEENT, respiratory, and gastrointestinal symptoms compared to uninfected controls (n=113).
  • Infected children experienced worse Patient Reported Outcomes in domains including Pain, Fatigue, Global Health, Physical and Cognitive functioning, Mobility, and Sleep disturbances.
  • Cardiopulmonary findings were similar between infected and uninfected cohorts at baseline.

Conclusions:

  • Pediatric SARS-CoV-2 infection is associated with increased symptom reporting and diminished quality of life.
  • Longitudinal data from the PECOS study will enhance understanding of the long-term effects of COVID-19 in children, aiding in the identification of sequelae and contributing factors.
Abstract

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