Effects of intravenous anesthesia and inhalation anesthesia on postoperative inflammatory markers in patients with esophageal cancer: a retrospective study
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View abstract on PubMed
Summary
This summary is machine-generated.Total intravenous anesthesia (TIVA) and inhalational anesthesia (INHA) showed no significant difference in inflammatory markers like neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) after esophageal cancer surgery.
Area Of Science
- Oncology
- Anesthesiology
- Immunology
Background
- Prognostic significance of inflammatory markers in cancer patients is established.
- Esophageal cancer surgery involves assessing perioperative inflammatory responses.
- Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) are key inflammatory markers.
Purpose Of The Study
- To compare the impact of total intravenous anesthesia (TIVA) versus inhalational anesthesia (INHA) on postoperative inflammatory markers (NLR, PLR, SII) in esophageal cancer patients.
- To determine if TIVA offers advantages over INHA in modulating the perioperative inflammatory response.
- To analyze the effect of different anesthesia methods on key indicators of systemic inflammation.
Main Methods
- Retrospective review of electronic medical records for patients undergoing esophagectomy between January 1, 2014, and December 31, 2016.
- Patients were categorized into TIVA and INHA groups.
- Inverse probability of treatment weighting (IPTW) was used to control for confounding factors, followed by Mann-Whitney U or Kruskal Wallis tests for comparing inflammatory markers.
Main Results
- A total of 519 patients were initially identified, with 339 eligible for analysis (201 in TIVA, 138 in INHA).
- Post-IPTW analysis revealed no statistically significant differences in NLR, PLR, or SII between the TIVA and INHA groups on postoperative day 1 (P > 0.195) and day 3 (P > 0.180).
Conclusions
- Neither TIVA nor INHA demonstrated superiority in reducing the perioperative inflammatory response, as indicated by similar NLR, PLR, and SII levels.
- The choice between TIVA and INHA does not appear to significantly influence key systemic inflammatory markers following esophageal cancer surgery.
- These findings suggest that other factors may be more critical in managing the inflammatory response after esophagectomy.
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