Related Experiment Video
Updated: Jun 4, 2025

A Murine Model of Hemodialysis Access-Related Hand Dysfunction
Published on: May 31, 2022
The effect of workability-related factors in patients with end-stage kidney disease undergoing hemodialysis
Mahsa Motiei1, Mirsaeed Attarchi2, Elham Ramezanzadeh3
1Pediatric Diseases Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Background:
The disability of patients with end-stage kidney disease (ESKD) and the possibility of reducing the ability to work for patients who are receiving hemodialysis require extensive investigations worldwide. In this regard, we aimed to investigate employment status and its effect on a large group of work ability-related factors in these patients.
Methods:
A total of 191 patients with ESKD who were referred to the dialysis department of Guilan Educational and Medical Centers, Rasht, Iran, in 2023 participated. The demographic and occupational data, clinical characteristics, and laboratory findings of the patients were recorded. A work ability index questionnaire was used to record the ability to work.
Results:
According to the results, 37.7% of people undergoing hemodialysis were employed, 45.4% of those who were not employed, lost their jobs before, and 54.6% lost their jobs after starting hemodialysis. Patients with lower values of work ability index found to be significantly older, illiterate, with lower job satisfaction and high frequency of absence from their job. Also, they were unemployed individuals with high rates of disability and no history of job change (P < 0.05 for all). Additionally, current unemployment, history of job changes, and packed red blood cell transfusion were predictive variables of the ability to work in hemodialysis patients (P < 0.001, P = 0.046, P = 0.046).
Conclusions:
Our results illustrated that the employment rate is low among patients with ESKD even before starting hemodialysis. Patients with higher age, less education, disability and anemia are at higher risk of weak ability to work.
Related Concept Videos
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Heart Failure Drugs: Diuretics
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Renal Drug Excretion: Effect of Urine pH, Flow Rate, and Drug pKa
The pKa of a...
Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels
One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...

