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Updated: Jun 4, 2025
Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
Risk factors of severe conditions in hospitalized children with adenovirus infection and chest CT features
Shaofang Wang1, Shichao Kang2, Lili Guo3
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Dadao 1095(#), Wuhan, 430030, People's Republic of China.
Insights
Identifying risk factors for severe human adenovirus (HAdV) infection in children is crucial. Lower lymphocyte counts and higher CT consolidation scores indicate increased risk for severe HAdV disease in pediatric patients.
Area of Science:
- Pediatric Infectious Diseases
- Respiratory Viral Infections
- Medical Imaging
Background:
- Human adenovirus (HAdV) infections pose a significant risk for severe disease in children.
- Understanding the specific risk factors for severe HAdV outcomes remains a clinical challenge.
Purpose of the Study:
- To identify risk factors for severe HAdV infection in pediatric patients.
- Analyze epidemiological, clinical, and CT imaging features associated with disease severity.
Main Methods:
- Retrospective study of 267 children with HAdV infection (Oct 2016 - Sep 2021).
- Descriptive analysis of epidemiological, clinical, and outcome data.
- Semi-quantitative CT scoring for lung consolidation, ground-glass opacities, and emphysema.
Main Results:
- Significant differences in chest CT abnormalities and imaging characteristics between severe and mild HAdV cases.
- Higher incidence of co-infections and lower lymphocyte proportions in severe cases.
- Markedly increased consolidation proportions and scores in the lungs of severe HAdV patients.
Conclusions:
- Chest CT findings, co-infections, and lymphocyte counts can help identify children at high risk for severe HAdV disease.
- Findings support targeted, aggressive treatment strategies for at-risk pediatric HAdV patients.
Background:
Children infected with human adenovirus (HAdV) were at particularly high risk of developing severe disease, but the risk factors of severe conditions are poorly understood.
Objectives:
To explore the risk factors for developing into severe conditions in pediatric patients with HAdV infection by analyzing baseline epidemiological data, clinical characteristics, and computed tomography (CT) imaging features.
Methods:
In this retrospective study, 267 children with HAdV infection were included between October 2016 and September 2021 at Tongji Hospital, Wuhan, China. A descriptive analysis was conducted on the epidemiological and clinical data, as well as patient outcomes. CT manifestations were semi-quantitatively scored based on the presence of consolidation, ground-glass opacities, and emphysema in each lung lobe.
Results:
Our analysis revealed that there was a statistically significant difference in the rate of abnormalities observed on chest CT imaging (P = 0.007) and the imaging characteristics of chest CTs (P = 0.002) when comparing severe and mild cases. We found that co-infection with two or more additional pathogens occurred more frequently in severe cases. Additionally, the proportion of lymphocytes in laboratory tests was significantly lower in patients with severe conditions. Furthermore, both the proportions and scores of consolidations were markedly higher in each lung lobe among the severe cases.
Conclusions:
Our findings may assist in identifying children hospitalized with HAdV who are at increased risk for severe conditions, thereby facilitating more aggressive treatment and care strategies.
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