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Related Experiment Videos

Neonatal Th activation.

D W Cohen, R E Moncrieff, A J Silvergleid

    Transfusion
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    A rare case of Th activated red cells was found in an infant with bowel obstruction. This finding was unrelated to the infant's weakened A antigen activity or parental red cell profiles.

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    Area of Science:

    • Immunology
    • Hematology
    • Pediatrics

    Background:

    • Evaluating weakened A antigen activity in an infant with suspected sepsis and bowel obstruction.
    • Investigating unusual red blood cell antigen expressions in neonates.

    Observation:

    • A 1-month-old infant presented with clinical signs of bowel obstruction and suspected sepsis.
    • Red blood cells (RBCs) exhibited Th activation during serological testing.
    • Weakened A antigen activity was noted, prompting further investigation.
    • Neither Th activation nor weakened A antigen was detected in the parents' RBCs.

    Findings:

    • The infant's RBCs demonstrated Th activation, a phenomenon not inherited from parents.
    • Weakened A antigen activity was observed, but it was determined to be independent of Th activation.

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  • Commercial anti-A reagents showed weak reactivity with the infant's RBCs.

    • Implications:

    • Highlights the potential for novel red blood cell antigen expressions in infants with gastrointestinal issues.
    • Suggests that Th activation and weakened A antigen can occur independently, requiring careful serological interpretation.
    • Underscores the importance of comprehensive red blood cell phenotyping in complex pediatric cases.