[Uncommon Yet Severe: Metabolic Acidosis from Concurrent Use of Paracetamol and Flucloxacillin]
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View abstract on PubMed
Summary
This summary is machine-generated.Severe metabolic acidosis in a patient treated with flucloxacillin and paracetamol resolved after N-acetylcysteine and hemofiltration. This case highlights glutathione deficiency risk factors and starvation ketoacidosis.
Area Of Science
- Biochemistry
- Clinical Medicine
- Pharmacology
Background
- A 60-year-old polymorbid patient presented with severe metabolic acidosis.
- Acidosis developed during prolonged treatment with flucloxacillin and paracetamol.
Purpose Of The Study
- To investigate the cause of severe metabolic acidosis in a polymorbid patient.
- To describe the successful treatment of drug-induced and starvation-related acidosis.
Main Methods
- Analysis of metabolic acidosis triggers, including 5-oxoproline accumulation and ketoacidosis.
- Treatment with N-acetylcysteine and hemofiltration.
Main Results
- The patient's acidosis was attributed to 5-oxoproline accumulation (due to glutathione deficiency risk factors) and starvation ketoacidosis.
- Complete resolution of metabolic acidosis was achieved with N-acetylcysteine and hemofiltration.
Conclusions
- Flucloxacillin and paracetamol can contribute to severe metabolic acidosis in susceptible individuals.
- N-acetylcysteine and hemofiltration are effective treatments for complex metabolic acidosis cases.
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