Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Cells of the Innate Immune Response

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...

Immune Surveillance by NK Cells and Phagocytes

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...

Immune Response Against Viral Pathogens

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Targeting bacterial phosphotransferase system to prevent the dissemination of antibiotic resistance genes.

Acta pharmaceutica Sinica. B·2026

Same author

Characterization and preliminary heterosis evaluation of novel wheat genetically divergent populations.

Frontiers in plant science·2026

Same author

Ferroptosis in arterial atherosclerosis: mechanistic hypotheses, cell type specific vulnerabilities, translational biomarkers, and therapeutic opportunities.

Frontiers in immunology·2026

Same author

Suppressing Residual Low-Dimensional Phases in Bromide Perovskite LEDs Using a Dimethyl Phosphate Ionic Liquid.

The journal of physical chemistry letters·2026

Same author

Multi-omics profiling reveals systemic rejuvenation of the aged kidney through senolytic therapy.

NPJ Regenerative medicine·2026

Same author

Syntabulin promotes heart failure by enhancing SR-mitochondria tethering and impairing mitofission.

Cardiovascular research·2026

Search research articles

Related Experiment Video

Updated: Jun 4, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Neutrophils in oncolytic virus immunotherapy.

Danya Zhou^1,2, Chenglin Zhang³, Jingyi Sun³

¹Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Frontiers in Immunology

|December 19, 2024

Summary

Oncolytic virus therapy shows promise for cancer treatment. This review explores the understudied role of neutrophils in oncolytic virotherapy, aiming to improve future cancer treatments.

Keywords:

antiviral immune response cancer neutrophils oncolytic virus immunotherapy oncolytic viruses

More Related Videos

Production of High-Titer Recombinant Newcastle Disease Virus from Allantoic Fluid

Production of High-Titer Recombinant Newcastle Disease Virus from Allantoic Fluid

Published on: May 25, 2022

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Published on: June 19, 2015

Related Experiment Videos

Last Updated: Jun 4, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Production of High-Titer Recombinant Newcastle Disease Virus from Allantoic Fluid

Production of High-Titer Recombinant Newcastle Disease Virus from Allantoic Fluid

Published on: May 25, 2022

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Published on: June 19, 2015

Area of Science:

Oncology
Virology
Immunology

Background:

Oncolytic viruses are a promising cancer therapy, selectively targeting tumors and enhancing anti-tumor immunity.
Intratumoral and intravenous administration are common, but face challenges like immune responses and non-specific uptake.
Neutrophils, abundant leukocytes, have largely been overlooked in oncolytic virus therapy despite their antiviral roles.

Purpose of the Study:

To review the current literature on the role of neutrophils in oncolytic virus therapy.
To identify knowledge gaps regarding neutrophil function in this context.
To provide a theoretical basis for enhancing oncolytic virus efficacy through neutrophil modulation.

Main Methods:

Comprehensive literature search on neutrophils and oncolytic virus therapy.
Analysis of existing studies on immune cell involvement in oncolytic virotherapy.
Synthesis of findings to highlight the significance of neutrophils.

Main Results:

Oncolytic viruses demonstrate potential in cancer treatment, with various administration routes.
CD8+ T cells and NK cells are well-studied, but neutrophil involvement remains under-explored.
Emerging evidence suggests neutrophils play a crucial role in antiviral responses.

Conclusions:

Understanding neutrophil roles is critical for optimizing oncolytic virus therapy.
Further research into neutrophils could lead to improved cancer treatment strategies.
Targeting neutrophils may enhance the efficacy of oncolytic virus-based cancer therapies.